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Graph 15 The graph's vertical pathway show spontaneous oxidation of dopamine induced by high extraneuronal oxygen pressure. Addition of oxygen occurs twice. First oxygen is added to dopamine to form 6-Hydroxydopamine. In the second oxygen addition, 6-hydroxydopamine already has all its sites for oxygen occupied. So hydrogen peroxide (H2O2) is generated. The generation of hydrogen peroxide within sensitive neurons produces detrimental effects on nerve terminals. The graph's horizontal pathway of dopamine is enzymaticaly regulated. The enzyme dopamine-beta-oxidase catalyzes the addition of oxygen to dopamine to synthesize noradrenaline, an essential molecule of life.
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